9-芴甲基-N-琥珀酰亚胺基碳酸酯合成路线 （共 303 条）
反应条件
1: aq. ammonium hydroxide / dioxane / 1 h / 0 °C 2: 82 percent / H2O; toluene / Heating 3: 60 percent / N-bromosuccinimide / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 2h View Scheme
参考文献
Rene, Loic; Badet, Bernard
Synthetic Communications, 1996 , vol. 26, # 17 p. 3237 - 3239
反应条件
1: (4S,5S)-ethyl (4-isobutyl-2-oxo-oxazolidin-5-yl)acetate With lithium hydroxide in methanol T=20°C; 1.5 h; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With triethylamine in methanol T=20°C; 0.25 h; Further stages.;
参考文献
Konno, Hiroyuki; Kubo, Kanako; Makabe, Hidefumi; Toshiro, Emi; Hinoda, Naoyuki; Nosaka, Kazuto; Akaji, Kenichi
Tetrahedron, 2007 , vol. 63, # 38 p. 9502 - 9513
反应条件
sodium hydrogencarbonate in water; acetone 3 h; Ambient temperature; Yield given;
参考文献
Pons, Jean-Francois; Fauchere, Jean-Luc; Lamaty, Frederic; Molla, Annie; Lazaro, Rene
European Journal of Organic Chemistry, 1998 , # 5 p. 853 - 859
反应条件
sodium carbonate in 1,4-dioxane 1.5 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 25 p. 8940 - 8948
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water 48 h;
参考文献
Van Der Plas, Steven E.; Gea, An; Figaroli, Sara; De Clercq, Pierre J.; Madder, Annemieke
European Journal of Organic Chemistry, 2008 , # 9 p. 1582 - 1588
反应条件
triethylamine in tetrahydrofuran; water; acetonitrile T=20°C; 2 h;
参考文献
Tamamura, Hirokazu; Araki, Takanobu; Ueda, Satoshi; Wang, Zixuan; Oishi, Shinya; Esaka, Ai; Trent, John O.; Nakashima, Hideki; Yamamoto, Naoki; Peiper, Stephen C.; Otaka, Akira; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3280 - 3289
反应条件
sodium carbonate in 1,4-dioxane T=0 - 20°C; 1.5 h;
参考文献
Pearson, Daniel A.; Lister-James, John; McBride, William J.; Wilson, David M.; Martel, Lawrence J.; Civitello, Edgar R.; Dean, Richard T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1372 - 1382
反应条件
1: 91 percent / ethyldiisopropylamine / CH2Cl2 / 2.5 h / 23 °C 2: 4.14 g / oxalyl chloride; DMSO; triethylamine / CH2Cl2; tetrahydrofuran / -78 - 0 °C View Scheme
参考文献
Sasaki, Yusuke; Abe, Junko
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 1 p. 13 - 17
反应条件
sodium carbonate in 1,4-dioxane 1.) 0-5 deg C, 2 h, 2.) -> room temperature, 1.5 h;
参考文献
Jiang, Jianjun; Miller, Robert B.; Tolle, John C.
Synthetic Communications, 1998 , vol. 28, # 16 p. 3015 - 3019
反应条件
sodium hydrogencarbonate in water; acetone 2 h;
参考文献
Seebach, Dieter; Abele, Stefan; Sifferlen, Thierry; Haenggi, Martin; Gruner, Sibylle; Seiler, Paul
Helvetica Chimica Acta, 1998 , vol. 81, # 12 p. 2218 - 2243
