9-芴甲基-N-琥珀酰亚胺基碳酸酯合成路线 （共 303 条）
反应条件
sodium carbonate in 1,4-dioxane; water
T=0 - 20°C; 48.1667 h;
参考文献
Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming
Patent: US2006/63814 A1, 2006 ;
Location in patent: Page/Page column 20 ;
US 20060063814 A1
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C; 16 h; Inert atmosphere;
参考文献
Berube, Marie; Delagoutte, Florian; Poirier, Donald
Molecules, 2010 , vol. 15, # 3 p. 1590 - 1631
反应条件
1: (R)-N-Boc-2-amino-3-hydroxy-3-methylbutanoic acid With trifluoroacetic acid in dichloromethane
2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium hydrogencarbonate in water; acetone
参考文献
Valorisation HSJ, Societe en Commandite
Patent: US2009/48161 A1, 2009 ;
Location in patent: Page/Page column 40 ;
反应条件
1: 1-bromo-3-butynol With Gly-Ni-(S)-2-[N-(N-benzylpropyl)amino]benzophenone; sodium hydroxide in N,N-dimethyl-formamide
T=20°C; 0.1 h; Inert atmosphere;
2: With hydrogenchloride in methanol
T=60°C; 0.5 h;
3: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in 1,4-dioxane
T=0 - 20°C;
参考文献
Kawamoto, Steven A.; Coleska, Adriana; Ran, Xu; Yi, Han; Yang, Chao-Yie; Wang, Shaomeng
Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1137 - 1146
反应条件
sodium carbonate in 1,4-dioxane; water
T=20°C;
参考文献
Le Roy, Isabelle; Mouysset, Dominique; Mignani, Serge; Vuilhorgne, Marc; Stella, Lucien
Tetrahedron, 2003 , vol. 59, # 21 p. 3719 - 3727
反应条件
potassium carbonate in water
T=20°C; 16.75 h;
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
sodium hydrogencarbonate in water; acetone
T=20°C;
参考文献
Agarkov, Anton; Greenfield, Scott J.; Ohishi, Takahiro; Collibee, Scott E.; Gilbertson, Scott R.
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8077 - 8085
反应条件
triethylamine in water; acetonitrile
T=20°C; 1 h;
参考文献
Hondal; Nilsson; Raines
Journal of the American Chemical Society, 2001 , vol. 123, # 21 p. 5140 - 5141
反应条件
1: 66 percent / i-Pr2NEt / tetrahydrofuran / 16 h
2: (COCl)2; DMSO; i-Pr2NEt / CH2Cl2 / -78 - 0 °C
View Scheme
参考文献
Sternson; Wong; Grozinger; Schreiber
Organic letters, 2001 , vol. 3, # 26 p. 4239 - 4242
反应条件
N-ethyl-N,N-diisopropylamine in water; acetonitrile
pH=8 - 9;
参考文献
Lindner, Simon; Michler, Christina; Leidner, Stephanie; Rensch, Christian; Waengler, Carmen; Schirrmacher, Ralf; Bartenstein, Peter; Waengler, Bjoern
Bioconjugate Chemistry, 2014 , vol. 25, # 4 p. 738 - 749
