FMOC-L-丝氨酸甲酯合成路线 （共 14 条）
反应条件
aluminium trichloride; N,N-dimethyl-aniline in dichloromethane
参考文献
European Journal of Organic Chemistry, , # 21 p. 4437 - 4441
反应条件
1: 92 percent / 4-dimethylaminopyridine; pyridine / 16 h / -5 °C 2: 84 percent / NaI / acetone / 48 h / 20 °C View Scheme
参考文献
Smyth; Burke Jr.
Tetrahedron Letters, 1994 , vol. 35, # 4 p. 551 - 554
反应条件
1.1: 94 percent / pyridine 2.1: 92 percent / NaI / acetone / 20 °C 3.1: Zn; 1,2-dibromoethane; Me3SiCl / dimethylformamide / 2 h / 35 °C 3.2: 57 percent / Pd(PPh3)2Cl2 / dimethylformamide 4.1: 60 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Tabanella, Stefania; Valancogne, Ingrid; Jackson, Richard F W
Organic and biomolecular chemistry, 2003 , vol. 1, # 23 p. 4254 - 4261
反应条件
1.1: pyridine / 7 h / 0 °C
2.1: lithium triethylborohydride / tetrahydrofuran / 0 °C / Inert atmosphere
2.2: 0 °C
3.1: trimethyl tin hydroxide / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
View Scheme
参考文献
Schroll, Alayne L.; Hondal, Robert J.; Flemer, Stevenson
Journal of Peptide Science, 2012 , vol. 18, # 3 p. 155 - 162
