3-甲氧基羰基-2-甲基-丙酸氯合成路线 （共 5 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 54 ;
US 20120178748 A1
反应条件
1: H2 / Pd/C / methanol / 4 h / 20 °C
2: (COCl)2; DMF / tetrahydrofuran / 1 h / 0 - 20 °C
View Scheme
参考文献
Uchiro, Hiromi; Nagasawa, Koh; Aiba, Yasuyuki; Kobayashi, Susumu
Tetrahedron Letters, 2000 , vol. 41, # 21 p. 4165 - 4168
反应条件
1: toluene-4-sulfonamide / 48 h / 40 °C
2: hydrogen / palladium 10 on activated carbon / methanol / 2 h / 20 °C
3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
US 20120178748 A1
反应条件
potassium hydroxide; oxalyl dichloride
1.) methanol, 5 deg C, 50 h, 2.) benzene, 35 deg C, 3 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Almquist; Crase; Jennings-White; Meyer; Hoefle; Smith; Essenburg; Kaplan
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1292 - 1299
反应条件
1: PtO2; methyl acetate / Hydrogenation.Bei zum Schluss bei 5 at
2: pyridine; thionyl chloride
View Scheme
参考文献
Baker et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 149,153
