1,2,3,4-四氢-6,7-二甲氧基-2-[2-(4-硝基苯基)乙基]异喹啉合成路线 (共 3 条)
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide T=100°C; 12 h; Industry scale;
参考文献
HANMI SCIENCE CO., LTD
Patent: US2012/330020 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
1: PBr3 / diethyl ether 2: 14.5 g / K2CO3 / dimethylformamide / 6 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol P=760.051 Torr; 18 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/33101 A1, 2005 ;
Location in patent: Page/Page column 13-14 ;
WO 2005/033101 A1