4-[2-(3,4-二氢-6,7-二甲氧基-2(1h)-异喹啉)乙基]-苯胺合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol P=760.051 Torr; 18 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/33101 A1, 2005 ;
Location in patent: Page/Page column 13-14 ;
WO 2005/033101 A1
反应条件
1: 14.5 g / K2CO3 / dimethylformamide / 6 h / 100 °C 2: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: PBr3 / diethyl ether 2: 14.5 g / K2CO3 / dimethylformamide / 6 h / 100 °C 3: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: SOCl2 / 3 h / Heating 2: NaHCO3 / acetone / 6 h / Ambient temperature 3: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 4: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: NaHCO3 / acetone / 6 h / Ambient temperature 2: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 3: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 12 h / 100 °C / Industry scale 2: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C / Industry scale View Scheme
