(S)-(+)-(2,2-二甲基-[1,3]-二氧戊环-4-基)-甲胺合成路线 （共 12 条）
反应条件
1: lead tetraacetate / tetrahydrofuran / 2 h / 15 °C
2: hydroxylamin-hydrochloride, triethylamin / tetrahydrofuran; methanol / 5 h / 10 °C
3: 71 percent / H2 / Raney-Nickel / aq. NH3 / 3 h / 3000.2 Torr
View Scheme
参考文献
Danklmaier, Johann; Hoenig, Helmut
Liebigs Annalen der Chemie, 1988 , p. 1149 - 1154
反应条件
1: triethylamine / dichloromethane / 8 h
2: sodium azide / N,N-dimethyl-formamide / 20 h / 65 °C
3: triphenylphosphine / water; tetrahydrofuran
View Scheme
参考文献
Doboszewski, Bogdan; Groaz, Elisabetta; Herdewijn, Piet
European Journal of Organic Chemistry, 2013 , # 22 p. 4804 - 4815
