4,4-二甲基-2-(3-硝基苯基)-4,5-二氢-1,3-恶唑合成路线 （共 3 条）
反应条件
1: With tert-butyl methyl ether; nitric acid in tetrahydrofuran
T=0°C;
2: With sulfuric acid in dichloromethane
T=0°C; 1 h; Further stages.;
参考文献
Zhang, Pingsheng; Cedilote, Miall; Cleary, Thomas P.; Pierce, Michael E.
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8659 - 8664
参考文献
Gordey, Erin E.; Yadav, Paras N.; Merrin, Marcus P.; Davies, Jill; Ward, Steven A.; Woodman, Grant M.J.; Sadowy, Amber L.; Smith, Todd G.; Gossage, Robert A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4512 - 4515
反应条件
1: Oxone, NaHCO3, 1,1,1-trifluoroacetone / acetonitrile; H2O / Ambient temperature; Na2*EDTA, pH 7-7.5
2: 5percent NaOH / methanol / 12 h / Heating
View Scheme
参考文献
Yang, Dan; Yip, Yiu-Chung; Wang, Xue-Chao
Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7083 - 7086
