反应条件
1: 1.) Mg / 1.) ether, reflux, 1 h, 2.) ether, RT, overnight 2: 82 percent / p-toluenesulfonic acid / benzene / 4 h 3: 29 percent / CrO3 / acetic acid; H2O / 2 h / 30 - 35 °C 4: 95 percent / NaOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 1.) 120 deg C, 1 h, 2.) 190 deg C, 2 h View Scheme
参考文献
de Paulis; Betts; Smith; Mobley; Manier; Sulser
Journal of Medicinal Chemistry, 1981 , vol. 24, # 9 p. 1021 - 1026
