反应条件
1.1: dibenzoyl peroxide; N-bromosuccinmide / 4 h / 0 °C / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
2.2: 0.75 h / 0 °C
3.1: ethanol; SnCl2·2H2O / 0.5 h / 0 - 70 °C
4.1: hydrogenchloride; acetic acid / water / 1 h / 90 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ElexoPharm GmbH; HOYT, Scott, B.; PETRILLI, Whitney Lane; LONDON, Clare; XIONG, Yusheng; TAYLOR, Jerry Andrew; ALI, Amjad; LO, Michael; HENDERSON, Timothy, J.; HU, Qingzhong; HARTMANN, Rolf; YIN, Lina; HEIM, Ralf; BEY, Emmanuel; SAXENA, Rohit; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A.
Patent: WO2012/148808 A1, 2012 ;
WO 2012/148808 A1