2-羟基-1,4-萘醌合成路线 （共 313 条）
反应条件
potassium iodide; potassium hydroxide in water 4 h; Reflux;
参考文献
Tseng, Chih-Hua; Lin, Chang-Sheng; Shih, Pin-Keng; Tsao, Lo-Ti; Wang, Jih-Pyang; Cheng, Chih-Mei; Tzeng, Cherng-Chyi; Chen, Yeh-Long
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6773 - 6779
反应条件
1: 51 percent / CAN / acetonitrile / 2 h / 0 °C 2: 82 percent / mCPBA / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Lee, Yong Rok; Kim, Byung So; Jung, Yong Ug; Koh, Wha Soo; Cha, Jin Soon; Kim, Nam Woo
Synthetic Communications, 2002 , vol. 32, # 20 p. 3099 - 3105
反应条件
potassium hydroxide; potassium iodide 2.) HMPT, 45 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Schaffner-Sabba, Karl; Schmidt-Ruppin, Karl H.; Wehrli, Walter; Schuerch, ALfred R.; Wasley, Jan W. F.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 990 - 994
反应条件
perchloric acid; iron(III) chloride in acetic acid 6 h; Heating;
参考文献
Singh, Prem K.; Khanna, Rajinder N.
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3753 - 3754
反应条件
hydrogenchloride; acetic acid T=80°C; 1.5 h;
参考文献
Tournaire; Caujolle; Payard; Commenges; Bessieres; Bories; Loiseau; Gayral
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 6 p. 507 - 511
反应条件
potassium hydroxide; potassium iodide 2.) HMPT, 45 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Schaffner-Sabba, Karl; Schmidt-Ruppin, Karl H.; Wehrli, Walter; Schuerch, ALfred R.; Wasley, Jan W. F.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 990 - 994
反应条件
in neat (no solvent) T=100°C; P=750.075 Torr; 0.05 h; Microwave irradiation;
参考文献
Devi Bala, Balasubramanian; Muthusaravanan, Sivasubramanian; Perumal, Subbu
Tetrahedron Letters, 2013 , vol. 54, # 29 p. 3735 - 3739
参考文献
Fieser et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3177
参考文献
Fieser et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3177
反应条件
1: 2-hydroxynaphthalene-1,4-dione With triethylamine in ethyl acetate T=5 - 10°C; 1 h; 2: acetic anhydride in ethyl acetate T=5 - 10°C; 4.5 h;
参考文献
Nardi, Antonio; Sada, Mara; Salvi, Annibale; Maiorana, Stefano
Patent: US2010/137644 A1, 2010 ;
Location in patent: Page/Page column 3-4 ;
