2,4,6-三甲氧基苯甲醛合成路线 （共 65 条）
反应条件
1: AlBr3 / acetonitrile / 5 h / 20 °C
2: (C2H5)3SiH / trifluoroacetic acid / 20 °C
3: BF3*Et2O
View Scheme
参考文献
Redda, Kinfe; Mills, Chavonda Janeebra; Maleeva, Nelly
Patent: US2012/264820 A1, 2012 ;
反应条件
1: diethyl ether
2: aqueous H2SO4; ethanol
View Scheme
参考文献
Kenyon; Mason
Journal of the Chemical Society, 1952 , p. 4964,4966
反应条件
1: 21.3 g / zinc amalgam, hydrochloric acid / acetic acid; H2O / 2 h / Heating
2: 18.0 g / phosphoryl chloride / 1.5 h / Ambient temperature
View Scheme
参考文献
Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 403 - 411
反应条件
iodine in tetrahydrofuran
T=20°C; Grignard reaction; 2 h;
参考文献
Wolska; Poplawski; Lozowicka
Polish Journal of Chemistry, 1998 , vol. 72, # 10 p. 2331 - 2341
反应条件
1: ethyl bromide With magnesium in diethyl ether
2 h;
2: 2,4,6-Trimethoxybenzaldehyde in diethyl ether; toluene
T=20°C; Grignard reaction;
参考文献
Sharma, Anuj; Joshi, Bhupendra P.; Sinha, Arun K.
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 12 p. 2231 - 2235
反应条件
1.1: boron tribromide / dichloromethane / -78 - 20 °C
1.2: Cooling with ice
2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
4.1: sodium hydroxide / methanol / 3 h / 20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378
反应条件
ammonium acetate
Heating;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1.1: boron tribromide / dichloromethane / -78 - 20 °C
1.2: Cooling with ice
2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
4.1: sodium hydroxide / methanol / 3 h / 20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
6.1: trichlorophosphate / 3.5 h / 0 - 80 °C
7.1: potassium hydroxide / methanol; water / 24.5 h / 0 - 20 °C
8.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378
反应条件
acetic acid in ethanol
Heating;
参考文献
Pande, Kalpana; Tandon, Manju; Bhalla, T. N.; Barthwal, J. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1133 - 1135
反应条件
1: 50 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 3 h / 20 °C
2: 41 percent / CuO / various solvent(s) / 63 h / Heating
View Scheme
参考文献
Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos
Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811
