4-氯-2,8-双(三氟甲基)喹啉合成路线 （共 5 条）
反应条件
trichlorophosphate T=110°C; 2 h;
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
反应条件
acetyl chloride in acetic acid T=25°C; 6 h;
参考文献
Babu, Konda Ramesh; Eeshwaraiah, Begari; Aravind, Dachepally; Meshram, Harshadas M.; Raju, Rallabaldi Madhusudan; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Monatshefte fur Chemie, 2008 , vol. 139, # 2 p. 179 - 181
反应条件
1: 1.) NaH / 1.) toluene, DMF, 0 - 5 deg C, 1 h, 2.) toluene, DMF, 5 - 10 deg C, 2 h 2: 95 percent / 30percent H2O2, acetic acid / 1 h / 70 °C View Scheme
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
反应条件
sodium hydride
1.) toluene, DMF, 0 - 5 deg C, 1 h, 2.) toluene, DMF, 5 - 10 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
