(1aR-(1aalpha,2beta,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-十四烷酸1a,2,5,5a,6,9,10,10a-八氢-5,5a-二羟基-4-(羟基甲基)-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲桥环戊并(a)环丙烯并(e)环癸烯-6-基酯合成路线 （共 4 条）
→
83036-62-8(1aR-(1aalpha,2beta,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-十四烷酸1a,2,5,5a,6,9,10,10a-八氢-5,5a-二羟基-4-(羟基甲基)-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲桥环戊并(a)环丙烯并(e)环癸烯-6-基酯
反应条件
sodium tetrahydroborate; cerium(III) chloride in ethanol
T=0°C; 0.0833333 h;
参考文献
Roeser, H.; Sorg, B.; Hecker, E.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 7 p. 1026 - 1030
→
83036-62-8(1aR-(1aalpha,2beta,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-十四烷酸1a,2,5,5a,6,9,10,10a-八氢-5,5a-二羟基-4-(羟基甲基)-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲桥环戊并(a)环丙烯并(e)环癸烯-6-基酯
反应条件
perchloric acid in methanol
0.75 h;
参考文献
Sorg, Bernd; Hecker, Erich
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982 , vol. 37, # 6 p. 748 - 756
→
83036-62-8(1aR-(1aalpha,2beta,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-十四烷酸1a,2,5,5a,6,9,10,10a-八氢-5,5a-二羟基-4-(羟基甲基)-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲桥环戊并(a)环丙烯并(e)环癸烯-6-基酯
反应条件
1: 4-(N,N-dimethylamino)pyridine / toluene / 2 h
2: 82 percent / 70 percent HClO4 / methanol / 0.75 h
View Scheme
参考文献
Sorg, Bernd; Hecker, Erich
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982 , vol. 37, # 6 p. 748 - 756
→
83036-62-8(1aR-(1aalpha,2beta,5beta,5abeta,6beta,8aalpha,9alpha,10aalpha))-十四烷酸1a,2,5,5a,6,9,10,10a-八氢-5,5a-二羟基-4-(羟基甲基)-1,1,7,9-四甲基-11-氧代-1H-2,8a-甲桥环戊并(a)环丙烯并(e)环癸烯-6-基酯
反应条件
1: 4-(N,N-dimethylamino)pyridine / toluene / 2 h
2: 82 percent / 70 percent HClO4 / methanol / 0.75 h
View Scheme
参考文献
Sorg, Bernd; Hecker, Erich
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982 , vol. 37, # 6 p. 748 - 756
