2-甲氧基甲基-5-甲基吡嗪 4-氧化物合成路线 （共 7 条）
反应条件
thionyl chloride; sodium methylate; sodium; zinc(II) chloride in methanol; pentane; benzene
参考文献
Farmitalia Carlo Erba S.p.A.
Patent: US4406901 A1, 1983 ;
反应条件
dihydrogen peroxide in acetic acid
T=40°C; 16 h;
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
反应条件
sodium hydride
1.) DMF, r.t.; 2.) DMF, 2 h, r.t.; Yield given. Multistep reaction;
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
反应条件
1: N-chlorosuccinimide, benzoyl peroxide / CCl4 / 8 h / Heating
2: 1 h / Heating
3: 72 percent / hydrogen peroxide / acetic acid / 16 h / 40 °C
View Scheme
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
反应条件
1: 77 percent / sodium borohydride / methanol; H2O / 2 h / Ambient temperature
2: 1.) sodium hydride / 1.) DMF, r.t.; 2.) DMF, 2 h, r.t.
View Scheme
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
反应条件
1: 1 h / Heating
2: 72 percent / hydrogen peroxide / acetic acid / 16 h / 40 °C
View Scheme
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
反应条件
1: 86 percent / diborane / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 3 h, 0 degC; 1 h, r.t.
2: 1.) sodium hydride / 1.) DMF, r.t.; 2.) DMF, 2 h, r.t.
View Scheme
参考文献
Cozzi; Pillan; Bertone; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 241 - 245
