(4S)-1-甲基-2-氧代咪唑啉-4-甲酸叔丁酯合成路线 （共 6 条）
反应条件
hydrogen; palladium in methanol P=760 Torr; 3 h; Ambient temperature;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4508727 A1, 1985 ;
US 4508727 A
反应条件
n-butyllithium in diethyl ether; benzene 1.) 0 deg C, 10 min, 2.) 0 deg C, 30 min;
参考文献
Journal of Organic Chemistry, , vol. 60, # 21 p. 6776 - 6784
反应条件
1: 89.8 percent / K2CO3 / acetone / 72 h / Ambient temperature 2: 98.2 percent / H2 / Pd / methanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
1: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 2: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 3: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
1: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 2: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 3: 1) K2CO3, 2) 15percent HCl/dioxane / 1) H2O, 2) rt, overnight View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
potassium tert-butylate
1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min; Multistep reaction;
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
