lithium hydroxide in water; isopropyl alcohol T=23°C; 1 h;

Multi-step reaction with 9 steps 1: 99 percent / imidazole / dimethylformamide / 3 h / 35 °C2: 1.) Cp2Zr(Cl)H, 2.) I2 / 1.) benzene, 40 deg C, 2.) hexane, 5 min3: 95 percent / <(Ph3P)4Pd>, n-BuNH2, CuI / benzene / 0.5 h4: 85 percent / AgNO3, KCN / aq. ethanol / 0.5 h / 30 °C5: 1.) Cp2Zr(Cl)H, 2.) I2 / 1.) THF, 35 deg C, 15 min6: 78 percent / n-butylamine, copper iodide / Pd<P(Ph3)>4 / benzene / 3 h / Ambient temperature7: Bu4NF / tetrahydrofuran / 2 h / Ambient temperature8: 85 percent9: 65 percent / Zn, MeOH / H2O / 5 h / 30 °C