4-(3-hydroxypropyl)benzonitrile合成路线 （共 16 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 4 h;
参考文献
WO2004/54584 A1, ;
Page/Page column 24 ;
WO 2004/054584 A1
反应条件
sodium tetrahydroborate in ethanol T=20°C; 18 h;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 1 p. 115 - 126
反应条件
potassium carbonate in tetrahydrofuran; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235731 B1, 2001 ;
反应条件
1: With methanol; lithium borohydride in diethyl ether 3 h; Heating / reflux; 2: With ammonium chloride in diethyl ether; water
参考文献
ASTRAZENECA AB
Patent: WO2005/123747 A1, 2005 ;
Location in patent: Page/Page column 53 ;
WO 2005/123747 A1
反应条件
1-methyl-pyrrolidin-2-one in water
参考文献
LABORATORIOS MENARINI S.A.
Patent: EP775133 B1, 2001 ;
反应条件
1: With sodium tetrahydroborate; cerium(III) chloride in acetonitrile T=-15 - 20°C; 2: With hydrogen; palladium on activated charcoal in ethyl acetate T=20°C; 4 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5492 - 5505
反应条件
hydrogenchloride; sodium chloride in tetrahydrofuran; water
反应条件
1: With potassium tert-butylate; copper (II) acetate monohydrate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; tert-butyl alcohol in toluene T=25°C; 25 h; Inert atmosphere; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran; toluene T=0°C; Overall yield = 80 percent;
参考文献
Wang, Guang-Hui; Bin, Huai-Yu; Sun, Miao; Chen, Shu-Wei; Liu, Ji-Hong; Zhong, Chong-Min
Tetrahedron, 2014 , vol. 70, # 12 p. 2175 - 2179
反应条件
1.1: thionyl chloride 2.1: NaBH4; CeCl3 / acetonitrile / -15 - 20 °C 2.2: H2 / Pd/C / ethyl acetate / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5492 - 5505
反应条件
1: benzene / 12 h / 20 °C 2: NaBH4 / ethanol / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 1 p. 115 - 126
