4-(3-hydroxypropyl)benzonitrile合成路线 （共 16 条）
反应条件
1: 78 percent / H2 / Raney-Ni / methanol / 760 Torr 2: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h View Scheme
参考文献
Pharmazie, , vol. 37, # 3 p. 178 - 182
反应条件
1: 70 percent / NaBH4 / methanol 2: 78 percent / H2 / Raney-Ni / methanol / 760 Torr 3: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h View Scheme
参考文献
Pharmazie, , vol. 37, # 3 p. 178 - 182
反应条件
hydrogenchloride; sodium nitrite 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h; Multistep reaction;
参考文献
Pharmazie, , vol. 37, # 3 p. 178 - 182
反应条件
Dess-Martin periodane in dichloromethane T=20°C; Dess-Martin oxidation;
参考文献
UNIVERSITEIT ANTWERPEN
Patent: WO2007/45496 A1, 2007 ;
Location in patent: Page/Page column 68-70; 75 ;
WO 2007/045496 A1
反应条件
1: 76 percent / H2SO4 / 24 h / Heating
2: 91 percent / SOCl2; pyridine / benzene / 2 h / 20 °C
View Scheme
参考文献
Baraldi; Cacciari; Romagnoli; Spalluto; Monopoli; Ongini; Varani; Borea
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 115 - 126
反应条件
sulfuric acid
24 h; Heating;
参考文献
Baraldi; Cacciari; Romagnoli; Spalluto; Monopoli; Ongini; Varani; Borea
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 115 - 126
