3-(3-羟基丙基)苯甲腈合成路线 （共 9 条）
反应条件
hydrogen; Wilkinson's catalyst in toluene
T=65°C; 15 h;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2168944 A1, 2010 ;
Location in patent: Page/Page column 154 ;
反应条件
1: With borane in tetrahydrofuran
T=0°C; 1 h;
2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran
T=0°C; 0.666667 h;
参考文献
Lee, B. C.; Choe, Y. S.; Lee, K. H.; Kim, B.-T.; Chi, D. Y.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S404 - S406
反应条件
palladium on charcoal in methanol
参考文献
Lilly Industries Limited
Patent: US4845110 A1, 1989 ;
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
Gensia Pharmaceuticals, Inc.
Patent: US5395970 A1, 1995 ;
反应条件
in tetrahydrofuran; water
参考文献
Lilly Industries Limited
Patent: US4845110 A1, 1989 ;
反应条件
1: 68 percent / NaBH4 / methanol
2: 85 percent / H2 / Raney-Ni / methanol / 760 Torr
3: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h
View Scheme
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
反应条件
1: 85 percent / H2 / Raney-Ni / methanol / 760 Torr
2: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h
View Scheme
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
反应条件
1.1: 81 percent / Pd(PPh3)4; LiCl / tetrahydrofuran / 12 h / 80 °C
2.1: BH3 / tetrahydrofuran / 1 h / 0 °C
2.2: 75 percent / aq. NaOH; H2O2 / tetrahydrofuran / 0.67 h / 0 °C
View Scheme
参考文献
Lee, B. C.; Choe, Y. S.; Lee, K. H.; Kim, B.-T.; Chi, D. Y.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S404 - S406
反应条件
hydrogenchloride; sodium nitrite
1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h; Multistep reaction;
参考文献
Vieweg; Wagner
Pharmazie, 1982 , vol. 37, # 3 p. 178 - 182
