2-氨基-3-(2,4-二氟苯基)-1-丙醇合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1 h;
参考文献
Marino, Sharon T.; Stachurska-Buczek, Danuta; Huggins, Daniel A.; Krywult, Beata M.; Sheehan, Craig S.; Nguyen, Thao; Choi, Neil; Parsons, Jack G.; Griffiths, Peter G.; James, Ian W.; Bray, Andrew M.; White, Jonathan M.; Boyce, Rustum S.
Molecules, 2004 , vol. 9, # 6 p. 405 - 426
反应条件
1: 69 percent / Ac2O; NaOAc / 1 h / Heating
2: 75.6 percent / acetone; H2O / 4 h / Heating
3: (+)-[(COD)Rh(S,S)-DuPHOS)]-BF4; H2 / methanol / 20 °C / 1551.44 Torr
4: SOCl2 / Heating
5: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Marino, Sharon T.; Stachurska-Buczek, Danuta; Huggins, Daniel A.; Krywult, Beata M.; Sheehan, Craig S.; Nguyen, Thao; Choi, Neil; Parsons, Jack G.; Griffiths, Peter G.; James, Ian W.; Bray, Andrew M.; White, Jonathan M.; Boyce, Rustum S.
Molecules, 2004 , vol. 9, # 6 p. 405 - 426
反应条件
1: 75.6 percent / acetone; H2O / 4 h / Heating
2: (+)-[(COD)Rh(S,S)-DuPHOS)]-BF4; H2 / methanol / 20 °C / 1551.44 Torr
3: SOCl2 / Heating
4: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Marino, Sharon T.; Stachurska-Buczek, Danuta; Huggins, Daniel A.; Krywult, Beata M.; Sheehan, Craig S.; Nguyen, Thao; Choi, Neil; Parsons, Jack G.; Griffiths, Peter G.; James, Ian W.; Bray, Andrew M.; White, Jonathan M.; Boyce, Rustum S.
Molecules, 2004 , vol. 9, # 6 p. 405 - 426
反应条件
1: (+)-[(COD)Rh(S,S)-DuPHOS)]-BF4; H2 / methanol / 20 °C / 1551.44 Torr
2: SOCl2 / Heating
3: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Marino, Sharon T.; Stachurska-Buczek, Danuta; Huggins, Daniel A.; Krywult, Beata M.; Sheehan, Craig S.; Nguyen, Thao; Choi, Neil; Parsons, Jack G.; Griffiths, Peter G.; James, Ian W.; Bray, Andrew M.; White, Jonathan M.; Boyce, Rustum S.
Molecules, 2004 , vol. 9, # 6 p. 405 - 426
反应条件
1: SOCl2 / Heating
2: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Marino, Sharon T.; Stachurska-Buczek, Danuta; Huggins, Daniel A.; Krywult, Beata M.; Sheehan, Craig S.; Nguyen, Thao; Choi, Neil; Parsons, Jack G.; Griffiths, Peter G.; James, Ian W.; Bray, Andrew M.; White, Jonathan M.; Boyce, Rustum S.
Molecules, 2004 , vol. 9, # 6 p. 405 - 426
