2-(5-溴吡啶-2-基)-2-氰基乙酸叔丁酯合成路线 (共 1 条)
反应条件
1: (1-(tert-butoxycarbonyl)-(4S)-fluoro-(2R)-pyrrolidinyl)acetonitrile With sodium hydride in dimethyl sulfoxide; mineral oil
T=18 - 25°C; 3 h;
2: 2,5-dibromo-pyridine in dimethyl sulfoxide; mineral oil
T=120°C; 6.5 h;
参考文献
Komine, Takashi; Kojima, Akihiko; Asahina, Yoshikazu; Saito, Tatsuhiro; Takano, Hisashi; Shibue, Taku; Fukuda, Yasumichi
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6558 - 6562