in neat (no solvent) T=160°C; 16 h;

1: ammonium hydroxide / chloroform / 2 h / 20 °C / |Inert atmosphere 2: triethylamine; titanium tetrachloride / dichloromethane / 1 h / 0 °C / |Inert atmosphere View Scheme

1: chlorosulfonic acid / dichloromethane / 0.75 h / 0 - 20 °C 2: water; ammonia / dichloromethane / 12 h / 20 °C 3: neat (no solvent) / 16 h / 160 °C View Scheme

in diethyl ether Irradiation; Further byproducts given;