2,6-二氟-3-硝基苯甲酸合成路线 （共 12 条）
反应条件
1: 42 percent / thionyl chloride / 1.) -15 to -5 deg C, 0.5 h, 2.) room temp., overnight
2: 88 percent / SnCl2*2H2O, conc. HCl / methanol / 20 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 1.) -15 to -5 deg C, 50 min, 2.) 0-5 deg C, 30 min
View Scheme
参考文献
Yoshida, Yoshiki; Barrett, David; Azami, Hidenori; Morinaga, Chizu; Matsumoto, Satoru; Matsumoto, Yoshimi; Takasugi, Hisashi
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2647 - 2666
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
2: sodium azide / CH2Cl2; dimethylformamide / 20 °C
3: CH2Cl2; dimethylformamide / Heating
4: 38 percent / H2 / palladium black / methanol / 20 °C
View Scheme
参考文献
Youai Co., Ltd.; SHIM, Eun Kyong; KIM, Nam Doo; SHIM, Tae Bo; KIM, Seung Yong
Patent: EP2647637 A2, 2013 ;
