(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(乙酰氧基)-1a,2,3,4,5a,6,7,8,9,9a,10,11-十二氢-11-羟基-5a,9,9-三甲基-13-亚甲基-5H-2,11a-乙桥苯并[5,6]环癸[1,2-b]环氧乙烯-5,12-二酮合成路线 （共 3 条）
→
83159-27-7(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(乙酰氧基)-1a,2,3,4,5a,6,7,8,9,9a,10,11-十二氢-11-羟基-5a,9,9-三甲基-13-亚甲基-5H-2,11a-乙桥苯并[5,6]环癸[1,2-b]环氧乙烯-5,12-二酮+
反应条件
jones reagent in acetone
3 h; ice-cooling;
参考文献
Fuji, Kaoru; Ito, Nozomu; Uchida, Itsuo; Fujita, Eiichi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1034 - 1037
→
83159-27-7(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(乙酰氧基)-1a,2,3,4,5a,6,7,8,9,9a,10,11-十二氢-11-羟基-5a,9,9-三甲基-13-亚甲基-5H-2,11a-乙桥苯并[5,6]环癸[1,2-b]环氧乙烯-5,12-二酮
反应条件
3-chloro-benzenecarboperoxoic acid
参考文献
Node; Ito; Fuji; Fujita
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2639 - 2640
→
83159-27-7(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(乙酰氧基)-1a,2,3,4,5a,6,7,8,9,9a,10,11-十二氢-11-羟基-5a,9,9-三甲基-13-亚甲基-5H-2,11a-乙桥苯并[5,6]环癸[1,2-b]环氧乙烯-5,12-二酮
反应条件
1: 51 mg / oxalic acid / methanol; H2O / 34 h / Heating
2: 78 mg / m-CPBA / CHCl3 / 192 h / in the dark
View Scheme
参考文献
Node, Manabu; Ito, Nozomu; Uchida, Itsuo; Fujita, Eiichi; Fuji, Kaoru
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1029 - 1033
