1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 81 percent / pyridine / Ambient temperature 6: 99 percent / pyridine / CHCl3 / Ambient temperature 7: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 8: t-BuOK / tetrahydrofuran / Ambient temperature 9: dimethylformamide / 80 °C 10: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 11: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 8: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: t-BuOK / tetrahydrofuran / Ambient temperature 3: dimethylformamide / 80 °C 4: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 5: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: dimethylformamide / 80 °C 2: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 3: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 2: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 3: 81 percent / pyridine / Ambient temperature 4: 99 percent / pyridine / CHCl3 / Ambient temperature 5: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 6: t-BuOK / tetrahydrofuran / Ambient temperature 7: dimethylformamide / 80 °C 8: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 9: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: t-BuOK / tetrahydrofuran / Ambient temperature 2: dimethylformamide / 80 °C 3: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 4: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 2: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 3: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 4: 81 percent / pyridine / Ambient temperature 5: 99 percent / pyridine / CHCl3 / Ambient temperature 6: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 7: t-BuOK / tetrahydrofuran / Ambient temperature 8: dimethylformamide / 80 °C 9: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 10: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 8: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: 90 percent / Et3N / 2-methyl-propan-2-ol / 1 h / Heating 2: 98 percent / KOH / dimethylsulfoxide / 2 h 3: 67.5 percent / 1N HCl / dioxane / 1.5 h / 90 °C View Scheme

1: 98 percent / KOH / dimethylsulfoxide / 2 h 2: 67.5 percent / 1N HCl / dioxane / 1.5 h / 90 °C View Scheme