1: Na2CO3 / acetone; H2O / 2.5 h / Ambient temperature 2: 91 percent / HCOOH, PPh3, Pd(OAc)2 / tetrahydrofuran / 4.5 h / Heating 3: 80 percent / NIS, MS, TfOH / CH2Cl2 / 2 h / -40 °C 4: H2 / Pd / methanol / 6 h / Ambient temperature 5: dimethylformamide / 2.5 h / 80 °C 6: 95 percent / NaOMe, MeOH / 0.75 h / Ambient temperature View Scheme