1,3-二甲基-2,6-二氧代-1,2,3,6-四氢嘧啶-4-甲醛合成路线 （共 9 条）
反应条件
PhMe2SiLi in tetrahydrofuran T=0°C;
参考文献
Saladino, Raffaele; Stasi, Luigi; Volpe, Gabriele; Nicoletti, Rosario; Botta, Maurizio
Heterocycles, 1998 , vol. 48, # 12 p. 2601 - 2610
反应条件
in tetrahydrofuran T=-20°C; 0.5 h;
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
反应条件
hydrogenchloride in tetrahydrofuran
3 h; Heating;
参考文献
Silverman, Richard B.; Groziak, Michael P.
Journal of the American Chemical Society, 1982 , vol. 104, # 23 p. 6434 - 6439
反应条件
sodium periodate in tetrahydrofuran; chloroform; water
T=20°C; 4 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; KUMAR, Sukkeerthi; THOMAS, Abraham; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/132017 A1, 2011 ;
Location in patent: Page/Page column 21-22 ;
WO 2011/132017 A1
反应条件
selenium(IV) oxide in acetic acid
T=100°C; 4 h;
参考文献
Walsh, Eileen B.; Wamhoff, Heinrich
Chemische Berichte, 1989 , vol. 122, p. 1673 - 1680
反应条件
1: 83 percent / NaOH / H2O / Ambient temperature
2: 1.) SeO2, 2.) HCl dry / 1.) glac. AcOH, 100 deg C, 4 h, 2.) reflux, overnight
3: 91 percent / 0.01M HCl / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Silverman, Richard B.; Groziak, Michael P.
Journal of the American Chemical Society, 1982 , vol. 104, # 23 p. 6434 - 6439
反应条件
hydrogenchloride; acetic acid
T=70°C; 1 h; Yield given;
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
反应条件
1: pyridinium tosylate / methanol / 36 h / Heating
2: 5percent aq. KOH / 0.25 h / 50 °C
3: 80percent aq. acetic acid, 2 N HCl / 1 h / 70 °C
View Scheme
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
反应条件
1: 5percent aq. KOH / 0.25 h / 50 °C
2: 80percent aq. acetic acid, 2 N HCl / 1 h / 70 °C
View Scheme
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
