3-氧代-2,3,5,7a-四氢-1H-吡咯里嗪-7-甲醛合成路线 （共 13 条）
反应条件
1: 1) lithiumdiisopropylamide, hexamethylphosphoramide 2) CH3OH / 1a) -78 deg C -> -20 deg C, 3 h 1b) -20 deg C, 1 h 2) -78 deg C, 15 min
2: red HgO, BF3*OEt2 / tetrahydrofuran; H2O / 3 h / 20 °C
View Scheme
参考文献
Chamberlin, A.Richard; Nguyen, Hoa D.; Chung, John Y.L.
Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1682 - 1688
反应条件
1: 26 percent / HgCl2, CaCO3 / aq. ethanol / 0.5 h / 25 °C
2: 1) lithiumdiisopropylamide, hexamethylphosphoramide 2) CH3OH / 1a) -78 deg C -> -20 deg C, 3 h 1b) -20 deg C, 1 h 2) -78 deg C, 15 min
3: red HgO, BF3*OEt2 / tetrahydrofuran; H2O / 3 h / 20 °C
View Scheme
参考文献
Chamberlin, A.Richard; Nguyen, Hoa D.; Chung, John Y.L.
Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1682 - 1688
反应条件
1.1: BF3*OEt2 / CH2Cl2 / 5 h / -20 - 20 °C
2.1: 40 mg / DMAP; pyridine / CH2Cl2 / 5 h / 20 °C
3.1: ozone / CH2Cl2 / -78 °C
3.2: triphenylphosphine / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Sarkar, Tarun K.; Hazra, Anindya; Gangopadhyay, Pulak; Panda, Niranjan; Slanina, Zdenek; Lin, Chun-Cheng; Chen, Hui-Ting
Tetrahedron, 2005 , vol. 61, # 5 p. 1155 - 1165
