4-[4-[4-(羟基二苯基甲基)-1-哌啶基]-1-丁炔-1-基]-alpha,alpha-二甲基-苯乙酸合成路线 (共 1 条)
反应条件
1: With toluene-4-sulfonic acid; PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in ethanol T=20°C; 24 h; 2: With sodium hydroxide in tetrahydrofuran T=20°C; 24 h; Heating; 3: With acetic acid in tetrahydrofuran Product distribution / selectivity;
参考文献
DIPHARMA FRANCIS S.r.I.
Patent: US2010/228034 A1, 2010 ;
Location in patent: Page/Page column 3 ;