1-叔丁氧基羰基-3-羟基-吡咯烷合成路线 （共 23 条）
参考文献
Abbott Laboratories
Patent: US2010/317680 A1, 2010 ;
US 20100317680 A1
反应条件
hydrogenchloride in methanol; water T=20°C;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: EP1953163 A1, 2008 ;
Location in patent: Page/Page column 20 ;
EP 1953163 A1
反应条件
pyridine T=0 - 20°C; 24 h;
参考文献
Cystic Fibrosis Foundation Therapeutics, Inc.
Patent: US8334292 B1, 2012 ;
Location in patent: Page/Page column 57 ;
US 8334292 B1
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2: tetrahydrofuran / 60 h / 95 °C / Sealed tube View Scheme
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sunose, Mihiro; Peakman, Torren M.; Charmant, Jonathan P. H.; Gallagher, Timothy; Macdonald, Simon J. F.
Chemical Communications, 1998 , # 16 p. 1723 - 1724
反应条件
triethylamine in dichloromethane T=0 - 20°C; 2.5 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0150 ;
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 2.08333 h; 2: With triethylamine in dichloromethane T=-78 - 20°C; 3 h;
参考文献
Cumbre Inc.
Patent: US2005/277633 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050277633 A1
反应条件
triethylamine in dichloromethane; water; dimethyl sulfoxide; ethyl acetate; benzene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235731 B1, 2001 ;
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 20 h / 95 °C 3: triphenylphosphine; water / tetrahydrofuran / 5 h / 20 - 50 °C / Cooling with ice View Scheme
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
反应条件
in toluene T=3 - 14°C; Product distribution / selectivity;
参考文献
TARGACEPT, INC.; TOLER, Steven M.; HOSFORD, David A.; LIPPIELLO, Patrick M.; DUNBAR, Geoffrey Charles; CALDWELL, William Scott; HAMEDANI, Parviz; BENCHERIF, Merouane
Patent: WO2011/112428 A2, 2011 ;
Location in patent: Page/Page column 28 ;
