2-氨基-5-三氟甲氧基苯甲酸合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 5 h;
参考文献
ASTRAZENECA AB
Patent: WO2003/101956 A1, 2003 ;
Location in patent: Page 47 ;
WO 03/101956 A1
反应条件
trifluoroacetic acid in dichloromethane T=25°C; 2 h;
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
potassium hydroxide; dihydrogen peroxide in water; acetic acid
反应条件
1.1: 99 percent / toluene / 100 °C 2.1: t-BuLi / pentane; tetrahydrofuran / 2 h / -50 °C 2.2: 81 percent / pentane; tetrahydrofuran / 25 °C 3.1: 96 percent / CF3COOH / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 12 p. 4693 - 4699
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 2 h / -50 °C 1.2: 81 percent / pentane; tetrahydrofuran / 25 °C 2.1: 96 percent / CF3COOH / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 12 p. 4693 - 4699
