(5-氨基-3-苯基吡啶并[3,4-b]吡嗪-7-基)-氨基甲酸乙酯合成路线 （共 7 条）
反应条件
potassium permanganate; magnesium sulfate in acetone
2 h;
参考文献
Temple Jr.; Wheeler; Elliott; Rose; Comber; Montgomery
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 91 - 95
反应条件
1: 62 percent / EtONa / ethanol / 1.) RT, 18 h, 2.) reflux, 12 h
2: 97 percent / conc. HCl / 18 h
3: 1.) Me2S*BH3, 2.) KMnO4 / 1.) THF, 20 h, 2.) acetone, 0.8 h
View Scheme
参考文献
Temple, Carroll; Rener, Gregory A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3044 - 3050
反应条件
1: 62 percent / EtONa / ethanol / 1.) RT, 18 h, 2.) reflux, 12 h
2: 97 percent / conc. HCl / 18 h
3: 1.) Me2S*BH3, 2.) KMnO4 / 1.) THF, 20 h, 2.) acetone, 0.8 h
View Scheme
参考文献
Temple, Carroll; Rener, Gregory A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3044 - 3050
反应条件
potassium permanganate; dimethylsulfide borane complex
1.) THF, 20 h, 2.) acetone, 0.8 h; Yield given. Multistep reaction;
参考文献
Temple, Carroll; Rener, Gregory A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3044 - 3050
反应条件
1: 97 percent / conc. HCl / 18 h
2: 1.) Me2S*BH3, 2.) KMnO4 / 1.) THF, 20 h, 2.) acetone, 0.8 h
View Scheme
参考文献
Temple, Carroll; Rener, Gregory A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3044 - 3050
反应条件
1: 74 percent / 4-pyrrolidinopyridine / 10 h / 80 °C
2: 37 percent / NaBH4 on alumina / dioxane / 2 h
View Scheme
参考文献
Temple Jr.; Rener; Comber
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2363 - 2367
反应条件
1: 91 percent / p-TsOH / 6 h / 140 °C
2: 41 percent / NaBH4 on alumina / dioxane / 2 h
View Scheme
参考文献
Temple Jr.; Rener; Comber
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2363 - 2367
