反应条件
1: 2-fluoro-4-bromo-aniline With potassium acetate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in DMF (N,N-dimethyl-formamide)
T=80°C; 2.5 h;
2: 3-bromo-4-amino-[3,2-c]-thienopyridine With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in DMF (N,N-dimethyl-formamide); water
80 h;
参考文献
Betschmann, Patrick; Burchat, Andrew; Calderwood, David; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin; Hrnciar, Peter; Michaelides, Michael; Rafferty, Paul
Patent: US2005/20619 A1, 2005 ;
Location in patent: Page 17-18 ;
US 20050020619 A1
