1-(4-溴苯基)-4-氯-1H-吡唑并[3,4-d]嘧啶合成路线 (共 6 条)
反应条件
in acetonitrile
T=200°C; 0.333333 h; Microwave irradiation;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
in 1,4-dioxane
T=200°C; 0.333333 h; Sealed tube;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
trichlorophosphate
Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/50946 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/050946 A1
反应条件
1: triethylamine / acetonitrile / 16 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: triethylamine / acetonitrile / 16 h / 0 °C / Inert atmosphere
2: hydroxylamine-o-sulphonic acid / acetonitrile / 16 h / 20 °C / Inert atmosphere; Molecular sieve
3: sodium hydroxide / dichloromethane; water / 6 h / Inert atmosphere
View Scheme
参考文献
Evans, Lindsay E.; Cheeseman, Matthew D.; Jones, Keith
Organic Letters, 2012 , vol. 14, # 13 p. 3546 - 3549
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2: 1,4-dioxane / 0.33 h / 200 °C / |Sealed tube
View Scheme
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885