4-甲氧基-2,3,5,6-四氟苯甲醇合成路线 （共 11 条）
反应条件
sulfuric acid; water T=50°C; 0.5 h;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1975147 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
potassium hydroxide in water; toluene T=50 - 60°C; 4.5 h; Heating / reflux;
参考文献
US6339176 B2, ;
Page column 5 ;
反应条件
potassium hydroxide; nitrogen; dimethyl sulfate in water; toluene
反应条件
sodium hydroxide; nitrogen in water; dimethyl sulfate
反应条件
sodium tetrahydroborate; zinc(II) chloride in diethylene glycol dimethyl ether 5 h; Reflux;
参考文献
Zhang, Deyan; Chen, Zizhan; Cai, Huihua; Zou, Xinzhuo
Journal of Fluorine Chemistry, 2009 , vol. 130, # 10 p. 938 - 941
反应条件
lithium methanolate in n-heptane T=95 - 105°C; 16 h; Heating / reflux; Product distribution / selectivity;
参考文献
SUMITOMO CHEMICAL CO LTD
Patent: JP2005/82501 A, 2005 ;
Location in patent: Page/Page column 9; 10 ;
反应条件
1: 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl alcohol With zirconium tetra-n-propoxide in propan-1-ol; xylene T=143 - 145°C; 2: 3-(2-methyl-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid With 2,6-di-tert-butyl-4-methyl-phenol in propan-1-ol; xylene T=145 - 147°C; 8 h; Product distribution / selectivity;
参考文献
US2005/113581 A1, ;
Page/Page column 9 ;
反应条件
pyridine in tetrahydrofuran
