Colletochlorin B合成路线 （共 12 条）
反应条件
1: 3-chloro-4,6-dihydroxy-2-methylbenzaldehyde With potassium hydroxide in methanol
12 h;
2: 3,7-dimethylocta-2,6-dienyl bromide in toluene
18 h; Reflux; Reagent/catalystSolvent;
参考文献
aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi
Patent: EP2636663 A1, 2013 ;
Location in patent: Paragraph 0120; 0121 ;
反应条件
sodium hydride in N,N,N',N',N'',N''-hexamethylphosphoric triamide; ethanethiol
T=120°C; 1.3 h;
参考文献
Saimoto; Ueda; Sashiwa; Shigemasa; Hiyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 4 p. 1178 - 1185
反应条件
diphosphorous tetraiodide in dichloromethane
0 degC, 25 min and room temp., 5 min;
参考文献
Saimoto; Ueda; Sashiwa; Shigemasa; Hiyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 4 p. 1178 - 1185
反应条件
diphosphorous tetraiodide in dichloromethane
0 degC, 25 min and room temp., 5 min;
参考文献
Saimoto, Hiroyuki; Kusano, Yukari; Hiyama, Tamejiro
Tetrahedron Letters, 1986 , vol. 27, # 14 p. 1607 - 1610
反应条件
in N,N-dimethyl-formamide
T=120°C; 1 h;
参考文献
Saimoto; Ueda; Sashiwa; Shigemasa; Hiyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 4 p. 1178 - 1185
反应条件
1: 99 percent / PCC / CH2Cl2 / Ambient temperature
2: 81 percent / NaH / C2H5SH; hexamethylphosphoric acid triamide / 1.3 h / 120 °C
View Scheme
参考文献
Saimoto; Ueda; Sashiwa; Shigemasa; Hiyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 4 p. 1178 - 1185
反应条件
1: LiAlH4 / diethyl ether / 0 °C
2: 99 percent / PCC / CH2Cl2 / Ambient temperature
3: 81 percent / NaH / C2H5SH; hexamethylphosphoric acid triamide / 1.3 h / 120 °C
View Scheme
参考文献
Saimoto; Ueda; Sashiwa; Shigemasa; Hiyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 4 p. 1178 - 1185
反应条件
2: LiAlH4 / diethyl ether
3: PyHCl*CrO3 / CH2Cl2
4: 64 percent / sodium ethanethiolate / hexamethylphosphoric acid triamide / 1) 100 deg C, 2 h, 2) 120 deg C, 1 h
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 597 - 600
反应条件
1: PyHCl*CrO3 / CH2Cl2
2: 70 percent / tetrabutylammonium fluoride / hexamethylphosphoric acid triamide / 2.5 h / 70 °C
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 597 - 600
反应条件
1: LiAlH4 / diethyl ether
2: PyHCl*CrO3 / CH2Cl2
3: 70 percent / tetrabutylammonium fluoride / hexamethylphosphoric acid triamide / 2.5 h / 70 °C
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 597 - 600
