反应条件
1: 1.) ethereal HCl, 2.) H2NOH*HCl, pyridine, 3.) HBr, CH3COOH
2: 1.76 g / 2 N HCl / 2 h / Heating
3: 4.78 g / aq. HCl, H2NOH*HCl, Na2SO4 / 1 h / Heating
4: 2.78 percent / aq. H2SO4 / a) 0 deg C, 1 h, b) 0 deg C to 75 deg C, 0.5 h
5: 595 mg / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Asselin; Humber; Voith; Metcalf
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 648 - 654
