3-乙酰基-5-溴-8-羟基-3,4-二氢-2H-1-萘酮合成路线 （共 3 条）
反应条件
sulfuric acid
Ambient temperature;
参考文献
Rao, A. V. Rama; Mehendale, A. R.; Reddy, K. Bal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1154 - 1164
反应条件
1: PTS acid / benzene / 6 h / Heating
2: H2NNH2*H2O, KOH / 4 h / 160 - 165 °C
3: H(1+)
4: 50 percent / AlCl3-NaCl / neat (no solvent) / 0.17 h / 180 °C
5: 96 percent / hydrogen / Pd/C / ethyl acetate / 1 h / 25 °C
6: PTS acid
7: epoxydation
8: 1) base, 2) acid
View Scheme
参考文献
Rao, A. V. Rama; Mehendale, A. R.; Reddy, K. Bal
Tetrahedron Letters, 1983 , vol. 24, # 10 p. 1093 - 1096
反应条件
1: PTS acid / benzene / 6 h / Heating
2: H2NNH2*H2O, KOH / 4 h / 160 - 165 °C
3: H(1+)
4: 50 percent / AlCl3-NaCl / neat (no solvent) / 0.17 h / 180 °C
5: 95 percent / K2CO3 / acetone
6: 85 percent / BF3*(C2H5)2O / CHCl3 / 1.5 h / Ambient temperature
7: CuCl / pyridine / 6 h / Ambient temperature
8: HgCl2 - HgO / H2O; acetonitrile / 1 h
View Scheme
参考文献
Rao, A. V. Rama; Mehendale, A. R.; Reddy, K. Bal
Tetrahedron Letters, 1983 , vol. 24, # 10 p. 1093 - 1096
