5-(溴甲基)-3-异恶唑羧酸 2-丙烯-1-基酯合成路线 （共 3 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=-20°C; 0.5 h;
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Patent: WO2005/121144 A1, 2005 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: 76 percent / K2CO3 / dimethylformamide / 7 h / 20 °C
2: 56 percent / PPh3; CBr4 / CH2Cl2 / 0.5 h / -20 °C
View Scheme
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
反应条件
1: 92 percent / Claisen's alkali / methanol / 0.5 h / 0 °C
2: 76 percent / K2CO3 / dimethylformamide / 7 h / 20 °C
3: 56 percent / PPh3; CBr4 / CH2Cl2 / 0.5 h / -20 °C
View Scheme
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
