1: 2-fluoro-3-iodopyridine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 1.16667 h; 2: cyclopent-3-enecarboxylic acid methoxy-methyl-amide in tetrahydrofuran; hexane T=-78°C; 3.25 h;

lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2 h;

tetrabutylammomium bromide; potassium acetate; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heck cyclization; 0.3 h;