5-(叔丁基)-2H-吡唑-3-甲酸乙酯合成路线 （共 5 条）
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=0 - 30°C; 15 h; 2: With acetic acid; hydrazine in tetrahydrofuran 2 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/18314 A2, 2007 ;
Location in patent: Page/Page column 143-144 ;
WO 2007/018314 A2
反应条件
hydrazine in ethanol T=20°C;
参考文献
Galapagos NV
Patent: WO2009/71706 A1, 2009 ;
Location in patent: Page/Page column 43 ;
WO 2009/071706 A1
反应条件
T=140°C; 0.75 h; microwave irradiation;
参考文献
Zrinski, Irena; Juribasic, Marina; Eckert-Maksic, Mirjana
Heterocycles, 2006 , vol. 68, # 9 p. 1961 - 1967
反应条件
1: ethanol 2: H2NNH2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4914 - 4919
反应条件
in toluene T=90°C; 2.5 h;
参考文献
Galapagos NV
Patent: WO2009/71706 A1, 2009 ;
Location in patent: Page/Page column 43-44 ;
WO 2009/071706 A1
