4-氯-5-碘-2,6-二甲基嘧啶合成路线 （共 3 条）
反应条件
ammonia in ethanol T=120°C; 12 h;
参考文献
Sakamoto; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2410 - 2416
反应条件
trichlorophosphate in toluene
1 h; Heating;
参考文献
Ellingboe, John W.; Collini, Michael D.; Quagliato, Dominick; Chen, James; Antane, Madelene; Schmid, Jean; Hartupee, Dale; White, Valerie; Park, C. Hyung; Tanikella, Tarak; Bagli, Jehan F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4251 - 4260
反应条件
1: 50 percent / iodine, 1N aq. NaOH / 2 h / Heating
2: 62 percent / POCl3 / toluene / 1 h / Heating
View Scheme
参考文献
Ellingboe, John W.; Collini, Michael D.; Quagliato, Dominick; Chen, James; Antane, Madelene; Schmid, Jean; Hartupee, Dale; White, Valerie; Park, C. Hyung; Tanikella, Tarak; Bagli, Jehan F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4251 - 4260
