(6Z,11E)-6,11-十六碳二烯-1-醇乙酸酯合成路线 （共 14 条）
反应条件
pyridine in tetrahydrofuran
1) -20 deg C, 0.5 h, 2) r.t., 3 h;
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
反应条件
1: 1) DIBAH, 2) I2 / 1) Et2O, hexane, a) r.t., 0.5 h, b) 40 deg C, 1 h, 2) Et2O, -78 deg C, 1 h
2: NaOMe / methanol / 4 h / 40 °C
4: 78 percent / acetonitrile / 24 h / Heating
6: 80 percent / Py / tetrahydrofuran / 1) -20 deg C, 0.5 h, 2) r.t., 3 h
View Scheme
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
反应条件
2: 78 percent / acetonitrile / 24 h / Heating
4: 80 percent / Py / tetrahydrofuran / 1) -20 deg C, 0.5 h, 2) r.t., 3 h
View Scheme
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
反应条件
1: NaOMe / methanol / 4 h / 40 °C
3: 78 percent / acetonitrile / 24 h / Heating
5: 80 percent / Py / tetrahydrofuran / 1) -20 deg C, 0.5 h, 2) r.t., 3 h
View Scheme
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
反应条件
1: 78 percent / acetonitrile / 24 h / Heating
3: 80 percent / Py / tetrahydrofuran / 1) -20 deg C, 0.5 h, 2) r.t., 3 h
View Scheme
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
反应条件
1: 1) BuLi / 1) hexane, THF, -30 deg C, 1 h, 2) THF, -50 deg C to r.t., 2 h
2: 1) DIBAH, 2) I2 / 1) Et2O, hexane, a) r.t., 0.5 h, b) 40 deg C, 1 h, 2) Et2O, -78 deg C, 1 h
3: NaOMe / methanol / 4 h / 40 °C
5: 78 percent / acetonitrile / 24 h / Heating
7: 80 percent / Py / tetrahydrofuran / 1) -20 deg C, 0.5 h, 2) r.t., 3 h
View Scheme
参考文献
Bestmann; Zeibig; Vostrowsky
Synthesis, 1990 , # 11 p. 1039 - 1047
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
反应条件
1: pyridinium-chlorochromate / CH2Cl2 / 2 h
2: 1) sodiumbis(trimethylsilyl)amide, 3) p-TSA/H2O / 1) THF, -78 deg C, 1h, 2) room temp., 12 h, 3) methanol, reflux, 3 h
3: 58 percent / pyridine
View Scheme
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
反应条件
1: 1) 9-BBN, 2) aq. NaOH/30 percent H2O2 / 1) THF, room temp., 1 h
2: pyridinium-chlorochromate / CH2Cl2 / 2 h
3: 1) sodiumbis(trimethylsilyl)amide, 3) p-TSA/H2O / 1) THF, -78 deg C, 1h, 2) room temp., 12 h, 3) methanol, reflux, 3 h
4: 58 percent / pyridine
View Scheme
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
反应条件
1: 1) sodiumbis(trimethylsilyl)amide, 3) p-TSA/H2O / 1) THF, -78 deg C, 1h, 2) room temp., 12 h, 3) methanol, reflux, 3 h
2: 58 percent / pyridine
View Scheme
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
