phosphorus oxytribromide T=150°C; 0.5 h;

1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C 2: 71.4 g / sulfuric acid / 5 h / 50 °C 3: 77 percent / phosphoric tribromide / 0.5 h / 150 °C View Scheme

1: 2,8-dibromo-3-fluoroquinoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane