phosphorus oxytribromide in various solvent(s) 2 h; Heating;

1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C 2: 81.8 g / hydrochloric acid / 5 h / 50 °C 3: 82 percent / phosphoric tribromide / various solvent(s) / 2 h / Heating View Scheme

1: 2-bromo-3-fluoro-5,7-dimethylquinoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane