1: 2-bromo-3-fluoroquinoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane

1.1: 90 percent / phosphoric tribromide / 0.5 h / 150 °C 2.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 94 percent / tetrahydrofuran; hexane View Scheme