4-(3-吲哚基)-4-氧代丁酸合成路线 (共 5 条)
反应条件
1: indole With tin(IV) chloride in dichloromethane T=20°C; 0.5 h; 2: succinic acid dichloride in nitromethane; dichloromethane T=20°C; Friedel-Crafts acylation; 10 h; Further stages.;
参考文献
Ottoni; Neder; Dias; Cruz; Aquino
Organic letters, 2001 , vol. 3, # 7 p. 1005 - 1007
反应条件
water; potassium hydroxide T=20°C; 24 h;
参考文献
McLaughlin, Emily C.; Norman, Matthew W.; Ko Ko, Thant; Stolt, Ingrid
Tetrahedron Letters, 2014 , vol. 55, # 16 p. 2609 - 2611
反应条件
1: ethyl magnesium iodide; diethyl ether 2: aqueous NaOH View Scheme
参考文献
Journal of the Chemical Society, , p. 2227,2228
参考文献
Journal of the Chemical Society, , p. 2227,2228
反应条件
magnesium; ethyl iodide 1.) anisole, 70 deg C, 30 min; 2.) anisole, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1221 - 1226