1-乙酰基-4-(2-羟基乙基)哌嗪盐酸盐合成路线 （共 10 条）
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/82866 A2, 2005 ;
Location in patent: Page/Page column 99-100 ;
WO 2005/082866 A2
反应条件
acetic anhydride in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; toluene
参考文献
AstraZeneca AB
Patent: US6559143 B1, 2003 ;
US 6559143 B1
反应条件
in tetrahydrofuran 36 h; Heating / reflux;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2007/102679 A1, 2007 ;
Location in patent: Page/Page column 109-110 ;
WO 2007/102679 A1
反应条件
in water T=25°C; ionic strength 0.2 M (KCl), structure-reactivity correlations in the aminolysis; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 54, # 9 p. 2153 - 2159
反应条件
in water T=25°C; ionic strength 0.2 M (KCl), structure-reactivity correlations in the aminolysis; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 54, # 9 p. 2153 - 2159
反应条件
in water T=25°C; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 55, # 5 p. 1676 - 1679
反应条件
in ethanol; water T=25°C; pH=8.2; KineticsMechanism; ConcentrationpH-value;
参考文献
International Journal of Chemical Kinetics, , vol. 43, # 12 p. 687 - 693
反应条件
in ethanol; water T=25°C; pH=8.86; KineticsMechanism; ConcentrationpH-valueSolvent;
参考文献
International Journal of Chemical Kinetics, , vol. 43, # 12 p. 687 - 693
反应条件
in ethanol; water T=25°C; pH=6.7; aq. phosphate buffer; KineticsMechanism; ConcentrationpH-valueSolvent;
参考文献
International Journal of Chemical Kinetics, , vol. 43, # 12 p. 687 - 693
反应条件
thionyl chloride in chloroform T=0°C; 1.83333 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/82866 A2, 2005 ;
Location in patent: Page/Page column 100 ;
WO 2005/082866 A2
