3-苄基-3-氮杂双环[3.2.1]辛-8-酮合成路线 （共 12 条）
反应条件
acetic acid in methanol T=20 - 80°C; 21 h; Inert atmosphere;
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
Location in patent: Page/Page column 64 ;
反应条件
1: paraformaldehyde; cyclopentanone With acetic acid in methanol 3 h; Heating / reflux; 2: benzylamine in methanol T=20°C; Heating / reflux;
参考文献
WO2006/35303 A1, ;
Page/Page column 29 ;
WO 2006/035303 A1
反应条件
1: With sulfuric acid; water in 1,4-dioxane 0.5 h; 2: With sodium hydroxide in 1,4-dioxane; water T=0°C; Product distribution / selectivity;
参考文献
Nippon Soda Co., Ltd.
Patent: EP2058303 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
1: With chloro-trimethyl-silane in acetonitrile T=20 - 50°C; 51 h; 2: With sodium hydrogencarbonate in water; acetonitrile
参考文献
WO2012/169649 A1, ;
Page/Page column 207; 208 ;
WO 2012/169649 A1
反应条件
formaldehyd; acetic acid 5 h; Heating / reflux;
参考文献
PFIZER LIMITED
Patent: WO2006/77499 A1, 2006 ;
Location in patent: Page/Page column 79 ;
WO 2006/077499 A1
反应条件
hydrogenchloride; water T=0 - 20°C;
参考文献
EP2058303 A1, ;
Page/Page column 12 ;
反应条件
hydrogenchloride; water 2 h; Heating / reflux;
参考文献
EP2058303 A1, ;
Page/Page column 11-12 ;
参考文献
Tetrahedron Letters, , vol. 51, # 13 p. 1790 - 1792
反应条件
1: (methoxymethyl)-triphenylphosphonium chloride With n-butyllithium in tetrahydrofuran
T=-50 - -25°C; 0.5 h;
2: 3-benzyl-3-azabicyclo[3.2.1]octan-8-one in tetrahydrofuran
T=-25 - 20°C;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
参考文献
Kumar, Naresh; Kaur, Kirandeep; Sinha, Sandeep; Gupta, Suman; Palle, Venkata P.; Chugh, Anita
Patent: US2009/12116 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
aluminum isopropoxide; cyclohexanol in toluene
17 h; Reflux;
参考文献
Nippon Soda Co., Ltd.
Patent: EP2184274 A1, 2010 ;
Location in patent: Page/Page column 7 ;
